Table 1.

Correlation analysis of bone mineralization density distribution (BMDD) with previously obtained biochemical outcomes from all studied animals. CaMean: the average Ca concentration of the mineralized bone area; CaLow: the amount of tissue area mineralized below 17.68 wt% Ca; CaPeak: the mode/peak calcium concentration; CaWidth: the width at half-maximum of the BMDD histogram peak indicating the heterogeneity of mineralization; CaHigh: the percentage of highly mineralized bone areas (above the average 95^th percentile of calcium concentrations of the wild-type baseline samples); PTH: parathyroid hormone; ALP: alkaline phosphatase.

Studied Site	BMDD Parameter	PTH	ALP	Serum Ca
Cortical diaphysis	CaMean	ns	ns	ns
	CaPeak	ns	ns	ns
	CaWidth	ns	ns	ns
	CaLow	0.62 ***	0.63 ***	−0.69 ***
	CaHigh	ns	ns	ns
Epiphyseal spongiosa	CaMean	−0.72 ***	−0.73 ***	0.63 ***
	CaPeak	ns	ns	ns
	CaWidth	ns	ns	ns
	CaLow	0.86 ***	0.81 ***	−0.60 ***
	CaHigh	ns	ns	ns
Metaphyseal spongiosa	CaMean	−0.63 ***	−0.60 ***	ns
	CaPeak	ns	ns	ns
	CaWidth	ns	ns	ns
	CaLow	0.82 ***	0.77 ***	−0.66 ***
	CaHigh	ns	ns	ns

Data show Spearman rank order (SRO) correlation coefficients for significant correlations. *** p < 0.001 (only results with p-values < 0.001 were considered significant). SRO coefficients > 0 indicate that both tested variables are increasing, while SRO coefficients < 0 indicate that one variable is decreasing while the other variable is increasing. ns = not significant