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. 2020 Oct 24;21(21):7906. doi: 10.3390/ijms21217906

Figure 1.

Figure 1

Impact of reelin in platelet activation and ITAM signaling. Extracellular reelin binds to ApoER2 and APP receptors at the platelet surface, resulting in platelet activation through RAC-1 activation. Additionally, reelin binding indirectly modulates GPIb signaling through APP and GPVI. Ligand binding to GPVI leads to dimerization of GPVI monomers, inducing auto-transphosphorylation of the GPVI-associated FcγR-chain ITAM motif through activation of Src-family kinases (SFKs). Besides, podoplanin binding to the CLEC-2 receptor causes activation of the CLEC-2-integrated hemITAM motif. Phosphorylated ITAM motifs lead to phosphorylation of SYK, which activates LAT kinases, being in direct proximity to PLCγ2. Activated PLCγ2 causes granule release, activation of protein kinase C (PKC), and activation of RAC1 and RhoA through calcium influx leading to cytoskeletal reorganization. This figure was created using images from Servier Medical Art Commons Attribution 3.0 Unported License. (http://smart.servier.com). Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License”.