Figure 4.

PANX1 and NMDAR activation upon platelet activation and signaling. Collagen binding induces activation of Src-family kinases (SFKs) which in turn activates PANX1 channels. Activation of PANX1 leads to an exchange of calcium and ATP, both modulating platelet activation through intra-and extracellular pathways. ATP directly binds to P2X1 or is degraded to ADP and binds to the purineric receptors P2Y1/P2Y12, all inducing platelet activation. Additionally, NMDAR might influence PANX1 activation through Src kinases, but this remains unclear in platelets to date. Besides, NMDAR activation induces calcium mobilization resulting in platelet activation. In a feedback loop, activated platelets release glutamate, an essential ligand for NMDAR activation. This figure was created using images from Servier Medical Art Commons Attribution 3.0 Unported License. (http://smart.servier.com). Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License”.