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. 2020 Oct 28;21(21):8047. doi: 10.3390/ijms21218047

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptional differentiation during PC differentiation. (A) Relationship between the antagonistic B cell transcriptional network and the ASC transcriptional network according to the cell differentiation step during the primary extra-follicular response (left), follicular response (middle), and secondary extra-follicular response (right). (B) Representation of the stability of the transcriptional network during PC differentiation. According to this model, naïve B cells and memory B cells represent the stable cell type that durably expresses B cell transcriptional network factors, and PC represents the stable cell type that durably expresses ASC transcriptional network factors. Other cell types (e.g., lymphoblasts, centroblasts, centrocytes, pre-PB, and PB) are transient and transcriptionally unstable, being are the site of active antagonism between the B cell and ASC transcriptional networks. The decision point represents the cell fate choice point where the transcriptional switch between the B cell network and the ASC network occurs, irreversibly inducing the activation of the ASC program and the extinction of the B cell program.