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Outline of the action of HiP-8 (A) and the selective binding of HiP-8 to two-chain active HGF (B). Once HiP-8 binds to tcHGF, tcHGF cannot bind to MET (A). The sensorgram shows that HiP-8 selectively binds to tcHGF, but not to scHGF (B) [20].
