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Metabolic regulators and pathways governing thymocyte development. Upregulation of glucose metabolism is the foremost requirement of developing thymocytes regulated by Notch, PI3K–AKT–mTOR and Lkb1 signaling pathways during different stages of T cell development as depicted here. HSC: hematopoietic stem cells, DN: CD4−/CD8− double-negative thymocytes, DP: CD4+/CD8+ double-positive thymocytes, and SP: CD4+CD8− or CD8+CD4− single positive.
