Figure 1.

The pathophysiologic changes of polycystic ovary syndrome including cortical thickening and stromal hyperplasia; increased granulosa/theca cells and surrounding stromal tissues; increased intro-ovarian follicular fluid, such as an increased pro-inflammatory response and a decreased anti-inflammatory response; down-regulation and inflammation-related gene and theca-associated lymphocytes; and the dysfunction of angiogenesis within the ovary. All are apparently present in a polycystic ovary.