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. 2020 Oct 30;11:561537. doi: 10.3389/fphar.2020.561537

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Copyright © 2020 Shuvalov, Fedorova, Tananykina, Julia, Daks, Petukhov and Barlev

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ecdysterone attenuates energy metabolism of TNBC breast cancer cell lines. SeaHorse energy profiling (Energy Phonotype kit) of (A,B) MDA-MB-231 and (C,D) MDA-MB-468 cancer cell lines treated with 0, 250, 500, 750 or 1,000 µM Ecdy for 48 h. OCR–oxygen consumption rate (respiration), ECAR–extracellular acidification rate (glycolysis). Baseline–base (normal) respiration (OCR) or glycolysis (ECAR); Stressed - OCR and ECAR of cells under an induced energy demand (in the presence of stressor compounds–FCCP and olygomycin). Stressed OCR and ECAR reflect metabolic potential–percentage increase of stressed OCR over baseline OCR, and stressed ECAR over baseline ECAR. Metabolic Potential is the measure of cells’ ability to meet an energy demand via respiration and glycolysis. Results are shown as mean ± SEM of three experiments. *p < 0.05; **p < 0.01; n.s – not significant.

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