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. 2020 Oct 30;11:561537. doi: 10.3389/fphar.2020.561537

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Copyright © 2020 Shuvalov, Fedorova, Tananykina, Julia, Daks, Petukhov and Barlev

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ecdysterone acts synergistically with doxorubicin to inhibit breast cancer cells. Results of MTT-test demonstrating the inhibition of (A) MCF7, (B) MDA-MB-231 (C) MDA-MB-468 cell lines by doxorubicin or ecdy along and in combination. Results are represented as the mean ± SD. *p < 0.05; **p < 0.01. Combination Index (CI) plots which reflect the distribution of CIs for different combinations of Dox/Ecdy concentrations, depending on their effects (rate of absorbance related to control) for: (D) MCF7, (E) MDA-MB-231 (F) MDA-MB-468 cells. CI plots were calculated using Chou-Talalay algorithms (CompuSyn software, http://www.combosyn.com/; Сhou, 2006). CI < 1 attests at the synergistic action of drugs; DRI estimates the extent to which the dose of doxorubicin in the combination with the indicated dose of Ecdy can be reduced to achieve effect levels that are comparable to those achieved with single agents.