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. 2020 Oct 30;11:561537. doi: 10.3389/fphar.2020.561537

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Copyright © 2020 Shuvalov, Fedorova, Tananykina, Julia, Daks, Petukhov and Barlev

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ecdysterone synergizes with doxorubicin and 2-DG to induce apoptosis and death of breast cancer cell lines. Annexin V-FITC/7-AAD profiles of (A) MCF7, (B) MDA-MB-231 breast cancer cells treated with doxorubicin, ecdysterone, and 2-DG alone or in combination for 48 h (flow cytometry). (C,D) Diagrams show the rate of apoptosis/total cell death for the same cell lines based on Annexin V-FITC/7-AAD data. (E,F) Diagrams show percent of live/dead cells. Results are calculated as the mean ± SEM of three experiments. *p < 0.05; **p < 0.01; n.s – not significant.

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