Figure 6.
Proposed role of the flexible C-terminal region in functional regulation of MINERVA. (a) Amino acid sequence of the C-terminal flexible region (Lys561–Phe574) is shown with known posttranslational modification sites and characteristic sequence motifs. Phosphorylation sites are highlighted in yellow. Short stretch of positively charged residues are in blue frame. Tandem SH3 domain-binding “(PXXPP)PψXP” motifs are in red frames. Keap1-interacting “DLGXnETGE” motif is in green frame. (b) Schematic summarizing known and proposed MINERVA function as a regulator of cell signaling. MINERVA is shown in orange.