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Assembly of NADPH oxidase multi-protein enzyme complexes with the P47 organizer family members. The core of the intracellular enzyme is formed via an interaction between a specific NOX oxidase and p22phox accompanied by activity-modulating organizers such as PX-SH3-structured proteins (NOXO1, TKS4/5, p47phox, p40phox). The extra-membrane-produced O2 is rapidly transformed into H2O2 and can passively diffuse through the cell-membrane. (Reviewed in Reference [144]).
