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. 2020 Oct 31;25(21):5064. doi: 10.3390/molecules25215064

Figure 2.

Figure 2

Antiviral activities of doxycycline at 5 µM against the SARS-CoV-2 IHUMI-003 strain in vitro. For full-time treatment, Vero E6 cells were pre-treated with doxycycline for 4 h and virus was then added for 48 h. For “entry” treatment, doxycycline was added to Vero E6 cells 4 h before viral infection and the virus-doxycycline mixture was replaced with fresh medium after 2 h post infection and was maintained for 46 h. For “post-entry” treatment, doxycycline was added 2 h post infection and was maintained for 46 h. Error bars represent the standard deviation of 10 experiments.