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Effects of compound 8 on lipopolysaccharide (LPS)-induced human IL-6 (a) and TNF-α (b) release in THP-1 cells. Differentiated THP-1 cells were treated with compound 8 and then cotreated with LPS for 24 h. The levels of proinflammatory cytokines were determined using ELISA. * p < 0.05, ** p < 0.05, and *** p < 0.005 indicate significance, according to the t-test.
