Figure 7.

MCPyV capsid reconstruction. (a) MCPyV capsid reconstructed from the 6ZLZ coordinate set. The capsid is oriented with the fivefold axis of symmetry (black pentagon) perpendicular to the view. VP1 proteins of the capsid are represented as α-carbon trace and colored according to the different chains. Blue capsomers are the α-pentamers located at the vertices of the capsid icosahedron. Side-chains of the mutant Phe residues are displayed as red sticks. (b) Detail of the interactions between the α-pentamer and the neighboring capsomers. (c) Detailed view of one of the Phe clusters created by the mutation Ile115Phe.