Table 1.

Comparative studies by PROVEAN and DynaMut for protein stability prediction.

Variants	PROVEAN Score; Effects	DynaMut; Effects
Asp69Val	−1.994; neutral	ΔΔG: 0.506 kcal/mol; stabilizing
Ser251Phe	−1.459; neutral	ΔΔG: 1.431 kcal/mol; stabilizing
Ile115Phe	−1.809; neutral	ΔΔG: 1.371 kcal/mol; stabilizing
Thr47Ser	−2.586; deleterious	ΔΔG: −0.442 kcal/mol; destabilizing
Tyr79∆	−4.793; deleterious

PROVEAN score cut-off = −2.5; ∆∆G: structural stability.