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. 2020 Mar 3;79(3):331–337. doi: 10.1017/S0029665120000117

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© The Author 2020

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — (Colour online) Metabolome, lipidome and adipose tissue transcriptome profiles in hepatic and muscle insulin resistance (IR). Upwards arrow indicates a positive association between hepatic or muscle IR, downwards arrow a negative association. Linear mixed model (Diogenes) or regression (Maastricht study) analyses with metabolite/lipid/gene expression as a dependent variable, hepatic insulin resistance indices/muscle insulin sensitivity indices as an independent variable, adjusted for BMI, waist:hip ratio and study centre included as a random effect (Diogenes), based on^(15–17). ScAT, subcutaneous adipose tissue; ECM, extracellular matrix.