Figure 5. Integrative structural dynamic characterization of the native and locally disordered intermediate ensembles in the domain swapping pathway of FoxP1.

a) Cartoon schematic of the domain swapping pathway of FoxP1, showing the connectivity of the different sub-ensemble conformations that account for the {I₂⁽¹⁾} and {I₂⁽²⁾} described in this work. b) Integrative information from the approaches used in this work to describe the energy landscape of the two dimeric intermediate ensembles. Our results highlight the linearity in the transition from the DS structure to the {I₂⁽²⁾}, although we cannot describe the sub-ensemble connectivity. In the structures, one subunit is highlighted in gray to differentiate the changes in each subunit.