Scheme 10.
Synthesis of (S)-N-{[3-[3-fluoro-4-[4-[5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-yl]-1-piperazinyl]phenyl-2-oxooxazolidin-5-yl]methyl}acetamide (S)-(48) from (S)-46 and chlorothiadiazole 19.
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