The effect of BSA, ITS or serum supplementation during IVC on (A) average glucose consumption, (B) lactate production, (C) lactate:(2 glucose) ratio and (D) pyruvate consumption (pmol/embryo/hour) of blastocysts resulting from BASAL-, PA- or HCOMBI-exposed oocytes. Data are presented as mean percentage ± SEM. Vertical superscripts (a, b) indicate significant differences between maturation conditions within the same IVC condition (p < 0.05). Horizontal superscripts (x, y, z) indicate significant difference between culture conditions within the same IVM condition (p < 0.05). Values labeled with “§” tend to be different from each other at p < 0.1 and > 0.05.