Table 1.

Antimicrobial susceptibility and resistance profiles of wild-type and multidrug-resistant strains of K. pneumoniae.

Strain ID	Carbapenemase Gene	MIC (μg/mL) for Antibiotic/Interpretative Categories													Carba NP Result
		SAM 1	TZP 1	FOX 2	CAZ 3	CRO 3	FEP 3	DOR 4	ETP 4	IPM 4	MEM 4	AMK 5	GEN 5	CIP 6
Kp 01	blaNDM, and blaVIM and/or blaIMP	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	32/I	≥16/R	=4/R	POS
Kp 02	blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	8/I	≥8/R	≥8/R	≥16/R	≥16/R	16/S	8/I	2/R	POS
Kp 03	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	4/I	≥8/R	≥8/R	≥16/R	≥16/R	4/S	≥16/R	2/R	POS
Kp 04	blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	≤2/S	≥16/R	1/R	POS
Kp 05	blaKPC	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	≥64/R	4/S	≥4/R	POS
Kp 06	blaKPC	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≤1/S	≥8/R	1/I	8/I	8/R	≤2/S	≤1/S	≤0.25/S	POS
Kp 07	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	32/I	≥16/R	≥4/R	POS
Kp 08	blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	16/S	8/I	≥4/R	POS
Kp 09	blaNDM, and blaVIM and/or blaIMP	≥32/R	≥128/R	8/S	8/I	≥64/R	32/R	0.25/S	≤0.5/S	≥16/R	0.5/S	16/S	4/S	≤0.25/S	POS
Kp 10	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	16/S	8/I	≥4/R	POS
Kp 11	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	8/S	≥16/R	2/R	POS
Kp 12	blaKPC, blaNDM, and blaVIM and/or blaIMP	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	8/I	≥16/R	16/S	≤1/S	≤0.25/S	POS
Kp 13	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	8/S	≤1/S	≤0.25/S	POS
Kp 14	blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	8/I	≥16/R	16/S	≥16/R	≥4/R	POS
Kp 15	blaKPC and blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	32/R	≥8/R	≥8/R	≥16/R	8/R	32/I	≥16/R	≥4/R	POS
Kp 16	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 17	NEG	8/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 18	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 19	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 20	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 21	NEG	8/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 22	NEG	8/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 23	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	0.5/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 24	NEG	8/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 25	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 26	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 27	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 28	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 29	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp 30	NEG	4/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG
Kp ATCC 2146	blaNDM	≥32/R	≥128/R	≥64/R	≥64/R	≥64/R	≥64/R	≥8/R	≥8/R	≥16/R	≥16/R	≥64/R	≥16/R	≥4/R	NEG
Ec ATCC 25922	NEG	≤2/S	≤4/S	≤4/S	≤1/S	≤1/S	≤1/S	≤0.12/S	≤0.5/S	≤0.25/S	≤0.25/S	≤2/S	≤1/S	≤0.25/S	NEG

Abbreviations: MIC, minimal inhibitory concentration; SAM, ampicillin/sulbactam; TZP, piperacillin/tazobactam; FOX, cefoxitin; CAZ, ceftazidime; CRO, ceftriaxone; FEP, cefepime; DOR, doripenem; ETP, ertapenem; IPM, imipenem; MEM, meropenem; AMK, amikacin; GEN, gentamicin; CIP, ciprofloxacin; Kp, K. pneumoniae; R, resistant; I, intermediate; S, susceptible; NEG, negative; POS, positive. ¹ Penicillin + β-lactamase inhibitors; ² Cephamycins; ³ Extended-spectrum cephalosporins; ⁴ Carbapenems; ⁵ Aminoglycosides; ⁶ Fluoroquinolones.