Table 3.
In vitro antibacterial and bactericidal activity of ΔM2 against wild-type and multidrug-resistant strains of K. pneumoniae and P. aeruginosa.
| K. pneumoniae (n) | MIC (μg/mL) | MBC (μg/mL) | P. aeruginosa (n) | MIC (μg/mL) | MBC (μg/mL) | p-Value 1 |
|---|---|---|---|---|---|---|
| WTKp (15) | 4–8 | 4–8 | WTPa (15) | 8 | 8 | 0.1833 |
| MDRKp (15) | 8–16 | 8–16 | MDRPa (15) | 8–16 | 8–16 | 0.0016 |
| Ec ATCC 25922 | 4–8 | 4–8 | Pa ATCC 27853 | 4–8 | 4–8 | |
| Kp ATCC 2146 | 8–16 | 8–16 |
Abbreviations: MIC, minimal inhibitory concentration, MBC, minimal bactericidal concentration; WTKp, wild-type K pneumoniae; MDRKp, multidrug-resistant K pneumoniae; WTPa, wild-type P aeruginosa; MDRPa, multidrug-resistant P aeruginosa; Ec ATCC 25922, Escherichia coli ATCC 25922; Kp ATCC 2146, K pneumoniae ATCC 2146; Pa ATCC 27853, P aeruginosa ATCC 27853. 1 Significance level for the minimal inhibitory concentrations (MICs) between species, comparing independently wild-type strains and MDR strains.