Figure 1.

Effects of human adipose-derived stem cells (hASC) transplantation on motor function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease mice. (A) Experimental schemes: MPTP was injected into the abdominal cavity of mice at a concentration of 30 mg/kg for 5 consecutive days. One week after MPTP injection, hASCs (1 × 10⁶ cells/100 μL) were administered into the tail vein 6 times at 2-week intervals. Behavioral tests were performed 2 weeks after the last hASC transplant, and the mice were sacrificed for brain tissue sampling. (B) The weight of the mice was measured weekly during hASC transplantation, which did not differ between groups. (C) The latency time in the rotarod performance test was decreased in MPTP mice compared to that in control mice and significantly increased in the MPTP + hASC mice. All data are indicated as mean ± standard error (n = 9 mice per group). * p < 0.05 vs. Control and ## p < 0.01 vs. MPTP using one-way analysis of variance (ANOVA) and Bonferroni’s post hoc multiple comparisons test.