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. 2020 Oct 30;21(21):8129. doi: 10.3390/ijms21218129

Figure 4.

Figure 4

Effects of hASC transplantation on brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic (GDNF) expression in the striatum of MPTP-induced Parkinson’s disease mice. Western blotting analysis was performed using brain tissues of the striatum and substantia nigra regions in each group using anti-BDNF or GDNF antibodies. (A) Representative Western blots of TH in the striatum tissue lysates of each group using BDNF, GDNF, and GAPDH antibodies (n = 6 per group). (B–E) The graph was expressed as the ratio of GDNF (B), pro-BNDF (C), mature BDNF (D), and mature/pro-BDNF, and (E) normalized using β-actin internal control. All data are indicated as mean ± standard error (n = 6 per group). * p < 0.05 and ** p < 0.01 vs. Control, and # p < 0.05 vs. MPTP using one-way ANOVA test and Bonferroni’s multiple comparisons test.