α-SMA |
α-smooth muscle actin |
ACE |
angiotensin converting enzyme |
ACEIs |
angiotensin converting enzyme inhibitors |
Ac-SDKP |
N-acetyl-seryl-aspartyl-lysyl-proline |
ADAM17 |
tumor necrosis factor-α-converting enzyme (TACE) |
ALI |
acute lung injury |
Ang |
angiotensin |
APA |
aminopeptidase A |
APM |
aminopeptidase M |
ARBs |
angiotensin II type 1 receptor blockers |
ARDS |
acute respiratory distress syndrome |
AT1R |
angiotensin II type 1 receptor |
AT2R |
angiotensin II type 2 receptor |
BAL |
bronchoalveolar lavage |
BLM |
bleomycin |
CATA |
cathepsin A |
CINC-3 |
cytokine-induced neutrophil chemoattractant 3 |
COPD |
chronic obstructive pulmonary disease |
CxA |
carboxypeptidase A |
CXCL5 |
C-X-C motif chemokine 5 |
DABK |
des-Arg9-bradykinin |
DOCA |
deoxycorticosterone acetate |
FiO2
|
fraction of inspired oxygen |
GM-CSF |
granulocyte-macrophage colony-stimulating factor |
HD |
high dose |
ICU |
intensive care unit |
IL |
interleukin |
i.p. |
intraperitoneally |
i.v. |
intravenously |
KC |
C-X-C motif chemokine 1 |
LD |
low dose |
LPS |
lipopolysaccharide |
mACE2 |
membrane-bound angiotensin converting enzyme 2 |
MasR |
Mas receptor |
MCP-1 |
monocyte chemoattractant protein-1 |
MIP2 |
macrophage inflammatory protein-2 |
MLDAD |
mononuclear leukocyte-derived aspartate decarboxylase |
MrgD |
Mas-Related G-Protein Coupled Receptor D |
NEP |
neprilysin |
PaCO2
|
partial pressure of carbon dioxide |
PaO2
|
partial pressure of oxygen |
POP |
propyl oligopeptidase |
PKC-δ |
protein kinase C-δ |
RAS |
renin–angiotensin system |
rhACE2 |
recombinant human angiotensin converting enzyme 2 |
sACE2 |
soluble angiotensin converting enzyme 2 |
s.c. |
subcutaneously |
T2D |
type 2 diabetes mellitus |
TACE |
tumor necrosis factor-α-converting enzyme (ADAM17) |
TGF-β1 |
transforming growth factor β1 |
TLR |
toll like receptor |
TMPRSS2 |
transmembrane protease serine 2 |
TNF-α |
tumor necrosis factor-α |
WBC |
white blood cells |