Scheme 1.
Reagents and Conditions: (i) (CH3)3SI, NaH, DMSO, r.t. (ii) ZnI2, benzene, reflux. (iii) CH2O, KOH, ethylene glycol, reflux. (iv) 1. TDAP, CCl4, THF, −40 °C; 2. NaOMe, MeOH, reflux.
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