Table 1.
Participant demographics and clinical characteristics at baseline
| SMC tot. (n = 316) | SMC females (n = 200) | SMC males (n = 116) | p | |
|---|---|---|---|---|
| Age, mean (SD) | 76.1 (3.5) | 76.1 (3.3) | 76.1 (3.9) | NS |
| Plasma NFL, mean (SD), pg/mL | 30.0 (13.0) | 29.9 (11.8) | 30.2 (14.8) | NS |
| Plasma t-Tau, mean (SD), pg/mL | 4.5 (2.6) | 4.7 (2.4) | 4.3 (2.9) | NS |
| Amyloid PET SUVR, mean (SD) | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | NS |
| APOE ɛ4−, No. (%) | 254 (80) | 159 (79) | 95 (82) | |
| APOE ɛ4+, No. (%) | 62 (20) | 41 (21) | 21 (18) | |
| Cognitive score | ||||
| MMSE, mean (SD) | 28.7 (1.0) | 28.7 (1.0) | 28.6 (1.0) | NS |
| FCSRT, mean (SD) | 46.1 (2.0) | 46.1 (2.0) | 45.4 (2.1) | NS |
| Clinical characteristics | ||||
| AF, No. (%) | 28 (9) | 16 (8) | 12 (10) | NS |
| BMI, mean (SD), Kg/m2 | 25.2 (3.5) | 25.1 (3.8) | 25.5 (2.9) | NS |
| Diabetes, No. (%) | 15 (5) | 9 (4.5) | 6 (5) | NS |
| Dyslipidemia, No. (%) | 133 (42) | 80 (40) | 53 (45) | NS |
| Head trauma, No. (%) | 26 (8) | 20 (10) | 6 (5) | NS |
| HTA, No. (%) | 129 (41) | 71 (35) | 58 (50) | 0.013 |
| IHD, No. (%) | 35 (11) | 17 (8.5) | 18 (15) | 0.050 |
| Mood disorders, No. (%) | 85 (27) | 71 (35) | 14 (12) | < 0.001 |
| OSAS, No. (%) | 19 (6) | 8 (4) | 11 (9) | 0.049 |
| Plasma Vit. B12 deficiency, No. (%) | 6 (1.5) | 4 (1.5) | 2 (1) | NS |
AF atrial fibrillation, BMI body mass index, FCSRT free and cued selective reminding test, HTA arterial hypertension, IHD ischemic heart disease, MMSE Mini-Mental State Examination, NFL neurofilament light chain, OSAS obstructive sleep apnea syndrome, SD standard deviation, SMC subjective memory complaints, SUVR standardized uptake value ratio, t-Tau total Tau