Table 2.

Summary of effect of biological variables and their interactions on longitudinal plasma NFL and t-Tau

	NFLa	Sample	NFLa	Amyloid- group	NFLa	Amyloid+ group
Model	F value	P value	F value	P value	F value	P value
Sex	1.910	0.168	1.482	0.224	0.130	0.719
Age	19.071	< 0.001	2.382	0.002	2.765	0.001
APOE	0.071	0.790	1.067	0.379	2.569	0.041
Sex * Age	0.973	0.483	1.622	0.088	1.532	0.178
Sex * APOE	1.375	0.242	0.856	0.464	1.096	0.353
Age * APOE	0.930	0.526	1.367	0.191	1.326	0.195
	t-Taub	Sample	t-Taub	Amyloid− group	t-Taub	Amyloid+ group
Model	F value	P value	F value	P value	F value	P value
Sex	11.639	0.003	5.327	0.022	2.507	0.002
Age	2.320	0.105	1.472	0.186	1.651	0.090
APOE	0.286	0.593	1.598	0.178	1.022	0.399
Sex * Age	4.654	0.038	2.317	0.005	3.507	0.030
Sex * APOE	0.039	0.844	0.877	0.417	0.790	0.501
Age * APOE	0.802	0.667	1.452	0.085	1.550	0.210

^aDependent variable: NFL (pg/mL)

^bDependent variable: t-Tau (pg/mL)