Table 3.
Partial least square regression models
| Index | NFL VIPsa | t-TAU VIPsa |
|---|---|---|
| Sex | 0.01 | 1.83 |
| Age | 2.74 | 0.18 |
| t-TAU | 1.53 | |
| NFL | 0.82 | |
| Amyloid PET SUVR | 0.69 | 0.08 |
| APOE ɛ4 | 0.14 | 0.53 |
| Cognitive score | ||
| MMSE | 1.47 | 0.72 |
| FCSRT | 0.94 | 0.62 |
| Clinical characteristics | ||
| AF | 0.77 | 0.29 |
| BMI | 1.25 | 0.81 |
| Diabetes | 0.38 | 0.56 |
| Dyslipidemia | 0.06 | 0.34 |
| Head trauma | 0.20 | 0.53 |
| HTA | 1.27 | 0.22 |
| IHD | 1.21 | 0.47 |
| Mood Disorders | 0.01 | 1.19 |
| OSAS | 0.80 | 1.04 |
| Plasma Vit. B12 deficiency | 0.01 | 2.48 |
AF atrial fibrillation, BMI body mass index, FCSRT free and cued selective reminding test, HTA arterial hypertension, IHD ischemic heart disease, MMSE Mini-Mental State Examination, NFL neurofilament light chain, OSAS obstructive sleep apnea syndrome, SD standard deviation, SMC subjective memory complaints, SUVR standardized uptake value ratio, t-Tau total Tau, VIPs variable importance for the projection
aVIPs is considered significant when ≥ 1.5