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. 2020 Nov 5;21(21):8300. doi: 10.3390/ijms21218300

Figure 8.

Figure 8

Effects of prolonged (72 h instead of 48 h) preincubation with HDACi / HSP90i on cisplatin sensitivity in A2780CisR ovarian cancer cells. 72 h preincubation with panobinostat or combination of 72 h of panobinostat with 24 h of luminespib or HSP990 prior to 48 h cisplatin treatment increased cisplatin sensitivity in A2780CisR (A). pIC50 ± SEM values of cisplatin in A2780CisR using 72 h preincubation with panobinostat compared to A2780 (B). Results (IC50, pIC50, SEM, and shift factor) are summarized in Table S5. Statistical analysis was performed using t-test. Levels of significance: ns p > 0.05, ** p ≤ 0.01, *** p ≤ 0.001.