Table 1.

Cytotoxic activity of panobinostat, LMK235, luminespib and HSP990.

Cell Line	HDACi				HSP90i
	Panobinostat		LMK235		Luminespib		HSP990
	IC50 [nM]	pIC50 ± SEM	IC50 [nM]	pIC50 ± SEM	IC50 [nM]	pIC50 ± SEM	IC50 [nM]	pIC50 ± SEM
A2780	28.0	7.55 ± 0.02	847	6.07 ± 0.03	11.2	7.95 ± 0.06	20.1	7.70 ± 0.06
A2780CisR	28.2	7.55 ± 0.03	644	6.19 ± 0.02	16.4	7.78 ± 0.04	29.8	7.53 ± 0.02

Cell viability was determined by MTT assay after a 72 h incubation. Data shown are the mean of pooled data from at least three experiments each carried out in triplicate. Concentration effect curves are shown in Figure S2A,B.