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The relative mRNA expression of Casp-9 (A) and Casp-8 (B) in the SK-MEL3 cell line after treatment with 17.7 µg/mL rCTII. The expression of candidate genes was assessed by real-time PCR in the control and treated group. Our result illustrated that this protein potentially activated both intrinsic and extrinsic pathways related to apoptosis. Error bars display the ± SD. The independent t-tests assessed the p-values. p < 0.01 (**).
