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. 2020 Nov 5;25(21):5148. doi: 10.3390/molecules25215148

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The rational mRNA expression of Casp-8 and Casp-9 after the treatment with 17.7 µg/mL rCTII in the SK-MEL-3 cell line (A). The relative expression of matrix metallopeptidase 3 (MMP-3) after the treatment with rCTII (B). The expression of candidate genes was evaluated through real-time PCR in the control and treated group. Our result illustrated that this protein potentially activated the intrinsic pathway of apoptosis more than extrinsic pathways. In addition, there was a significant down-regulation in the expression level of MMP-3 in treated cancerous cells. Error bars display the ± SD. The independent t-tests assessed the p-values. p < 0.05 (*).