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A graphical illustration of our main findings. Fst288 muscle overexpression markedly increased insulin‐stimulated (but not basal) intracellular insulin signalling of AKT, TBC1D4, PAK1, and mTOR signalling via p70S6K. In lean insulin sensitive mice, muscle‐directed Fst288 overexpression increased skeletal muscle insulin‐stimulated glucose uptake. Fst288 completely normalized muscle glucose uptake in insulin‐resistant obese mice.
