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. 2020 Nov 13;13:147. doi: 10.1186/s13041-020-00690-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Representative images of amyloid plaque, microglia, and astrocyte expression in App-KI mice. a Upper panel shows localization of Aβ (red), Iba-1 (green), and GFAP (blue) in the cortico-hippocampus of App-KI at 2–6 months age. These are followed by individual images of Aβ, Iba-1, and GFAP (from top to bottom). Bottom panels are representative higher-magnification images of activated microglia and GFAP-reactive astrocytes around Aβ plaques. These panels (Merge) show localization of Aβ (light blue), Iba-1 (green), and GFAP (red) in the cortico-hippocampus of App-KI at 2–6 months of age. b–d Adult neurogenesis in hippocampus of App-KI mice. b Representative images of DCX and Ki-67 expression. (Scale bar: 100 µm) c Quantitative data of DCX-positive cells. Expression levels were reduced in the hippocampus of App-KI mice. d Quantitation of Ki-67–positive cells. Ki-67-positive cells (arrowheads) were less abundant in hippocampus of App-KI mice. Data are presented as means ± SEM (n = 4). *p < 0.05 (t-test)