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The relapse rate from remission in relation to the change in the consecutive ACPA titer level. a The ratio of consecutive ACPA titer was calculated, and the distribution is presented. b The relationship between the ratio of consecutive ACPA titer and the rate of relapse within 1 year from the second measurement in patients who achieved remission in two consecutive measurements. The Cochra0n–Armitage trend test was used to assess the trend. ***P < 0.001
