Table 1.
pH and percentage of the original propofol remaining when mixed with water and saline solution
| 10 μg mL− 1 | 20 μg mL− 1 | 30 μg mL− 1 | 40 μg mL− 1 | 50 μg mL− 1 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | |
| Percent Propofol Remaining when left in Isolation (mean ± SEM; n = 3) | ||||||||||||||||||||
| I | 102.3 ± 0.90 | 101.1 ± 1.03 | 100.5 ± 1.05 | 100.2 ± 1.04 | 102.3 ± 0.90 | 101.1 ± 1.03 | 100.5 ± 1.05 | 100.2 ± 1.04 | 102.3 ± 0.90 | 101.1 ± 1.03 | 100.5 ± 1.05 | 100.2 ± 1.04 | 102.3 ± 0.90 | 101.1 ± 1.03 | 100.5 ± 1.05 | 100.2 ± 1.04 | 102.3 ± 0.90 | 101.1 ± 1.03 | 100.5 ± 1.05 | 100.2 ± 1.04 |
| W | 101.1 ± 0.22 | 100.4 ± 2.37 | 100.6 ± 2.00 |
99.6 ± 1.94 * |
102.2 ± 2.27 | 102.1 ± 1.92 | 101.8 ± 1.48 | 101.6 ± 1.58 |
99.8 ± 0.20 a |
100.5 ± 0.54 d |
100.9 ± 0.35 d |
99.5 ± 0.72 | 101.6 ± 2.06 | 100.5 ± 1.80 | 100.3 ± 1.69 | 99.4 ± 1.56 |
99.8 ± 0.13 * a |
98.7 ± 0.21 * |
98.2 ± 0.13 | 98.0 ± 0.21 |
| 0.9% | 99.9 ± 0.48 |
99.4 ± 0.48 b |
98.6 ± 0.18 * b |
98.3 ± 0.27 |
100.5 ± 0.07 * d |
101.9 ± 0.15 * |
100.5 ± 0.39 | 99.1 ± 0.33 |
101.2 ± 0.32 ** d |
100.7 ± 0.89 | 99.5 ± 0.54 |
97.9 ± 0.12 b |
101.1 ± 0.78 |
98.9 ± 0.86 b |
97.9 ± 0.60 * b |
98.0 ± 0.54 * |
99.4 ± 0.12 # |
98.8 ± 0.28 * b |
98.1 ± 0.29 b |
98.0 ± 0.06 b |
| 20% | 100.0 ± 0.49 |
100.0 ± 0.48 d |
99.3 ± 0.06 d |
98.1 ± 0.10 b |
100.1 ± 0.12 |
99.7 ± 0.48 d |
99.3 ± 0.24 d |
98.9 ± 0.15 |
98.7 ± 0.58 # |
100.8 ± 0.59 d |
100.1 ± 0.83 | 99.0 ± 0.88 |
99.5 ± 0.19 # |
100.7 ± 0.16 d |
101.3 ± 0.37 a, b, d |
100.9 ± 0.32 a, b, d |
99.1 ± 0.15 # b |
97.9 ± 0.13 # |
97.9 ± 0.33 | 97.8 ± 0.41 |
| pH of Solution (mean ± SEM; n = 3) | ||||||||||||||||||||
| I | 7.69 ± 0.01 | 7.70 ± 0.02 | 7.76 ± 0.01 | 7.74 ± 0.00 | 7.69 ± 0.01 | 7.70 ± 0.02 | 7.76 ± 0.01 | 7.74 ± 0.00 | 7.69 ± 0.01 | 7.70 ± 0.02 | 7.76 ± 0.01 | 7.74 ± 0.00 | 7.69 ± 0.01 | 7.70 ± 0.02 | 7.76 ± 0.01 | 7.74 ± 0.00 | 7.69 ± 0.01 | 7.70 ± 0.02 | 7.76 ± 0.01 | 7.74 ± 0.00 |
| W | 7.69 ± 0.01 |
7.72 ± 0.03 d |
7.80 ± 0.03 | 7.78 ± 0.03 |
7.74 ± 0.01 # |
7.78 ± 0.02 d |
7.83 ± 0.03 | 7.81 ± 0.02 |
7.76 ± 0.01 # |
7.79 ± 0.02 d |
7.85 ± 0.02 |
7.82 ± 0.03 # |
7.70 ± 0.01 |
7.75 ± 0.02 d |
7.80 ± 0.03 | 7.78 ± 0.03 | 7.67 ± 0.02 |
7.61 ± 0.02 # |
7.65 ± 0.05 | 7.67 ± 0.03 |
| 0.9% | 7.65 ± 0.01 |
7.52 ± 0.03 ^ |
7.48 ± 0.00 ^ |
7.43 ± 0.01 ^ |
7.47 ± 0.04 ^ a, d |
7.46 ± 0.02 ^ |
7.46 ± 0.02 ^ |
7.36 ± 0.01 ^ a |
7.44 ± 0.02 ^ a, d |
7.45 ± 0.02 ^ |
7.52 ± 0.04 ^ |
7.34 ± 0.01 ^ a |
7.42 ± 0.02 ^ a, d |
7.21 ± 0.02 ^ a,b,c |
7.26 ± 0.02 ^ a,b,c |
7.24 ± 0.02 ^ a,b,c |
7.22 ± 0.01 ^ a |
7.23 ± 0.02 ^ a,b,c |
7.21 ± 0.01 ^ a,b,c |
7.20 ± 0.02 ^ a,b,c |
| 20% |
7.09 ± 0.02 ^ |
7.02 ± 0.00 ^ |
7.04 ± 0.01 ^ |
7.07 ± 0.02 ^ |
7.02 ± 0.02 ^ |
6.95 ± 0.01 ^ a |
6.98 ± 0.00 ^ a |
7.01 ± 0.01 ^ |
6.94 ± 0.01 ^ a, b |
6.98 ± 0.02 ^ |
6.98 ± 0.01 ^ a |
6.98 ± 0.01 ^ a |
6.93 ± 0.02 ^ a, b |
6.96 ± 0.01 ^ a |
6.95 ± 0.01 ^ a, b |
6.91 ± 0.01 ^ e |
6.92 ± 0.02 ^ a, b |
6.94 ± 0.00 ^ a |
6.97 ± 0.00 ^ a, b |
6.94 ± 0.00 ^ a,b,c |
I = in isolation, W = water, 0.9% = 0.9% saline, 20% = 20% saline
*P < 0.05 vs. 20% saline solution; **P < 0.03 vs. water and 20% saline solution; #P < 0.04 vs. propofol in isolation; ^P < 0.05 vs. all other reconstitution solutions
aP < 0.03 vs. 10 μg mL− 1; bP < 0.04 vs. 20 μg mL− 1; cP < 0.02 vs. 30 μg mL− 1; dP < 0.04 vs. 50 μg mL− 1; eP < 0.05 vs. all other concentrations