Table 2.
pH and percentage of the original remifentanil/propofol remaining over 24 h when mixed
| 10 μg mL− 1 | 20 μg mL− 1 | 30 μg mL− 1 | 40 μg mL− 1 | 50 μg mL− 1 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | 1 h | 6 h | 12 h | 24 h | |
| Percent Remifentanil Remaining in Remifentanil-Propofol Mixture (mean ± SEM; n = 3) | ||||||||||||||||||||
| W | 99.5 ± 2.40 | 81.5 ± 1.58 | 64.7 ± 2.49 | 43.3 ± 2.02 | 100.3 ± 3.47 | 84.4 ± 4.41 | 67.0 ± 2.34 | 46.7 ± 2.82 | 97.9 ± 0.72 | 83.1 ± 2.94 | 67.4 ± 3.42 | 48.2 ± 5.09 | 97.3 ± 0.63 |
81.7 ± 1.43 ^ |
66.0 ± 2.56 ^ |
45.3 ± 2.89 ^ |
97.7 ± 0.18 |
83.1 ± 0.53 ^ |
67.0 ± 0.73 | 46.9 ± 1.22 |
| 0.9% | 93.5 ± 0.61 |
70.5 ± 1.24 * |
53.8 ± 1.15 * |
35.0 ± 0.49 * d |
96.7 ± 0.95 |
74.1 ± 1.11 d |
58.6 ± 1.29 * a, d |
35.9 ± 1.91 * d |
96.0 ± 0.49 |
78.0 ± 0.85 a, b |
61.2 ± 1.36 a |
37.4 ± 1.34 d |
94.4 ± 0.74 * |
74.9 ± 0.98 * a, d |
56.7 ± 1.19 * d |
34.8 ± 1.56 * d |
95.6 ± 0.83 |
79.7 ± 1.01 * a |
65.6 ± 1.26 a |
46.2 ± 1.08 |
| 20% | 96.6 ± 2.02 | 80.8 ± 2.08 | 63.3 ± 1.13 | 45.2 ± 2.30 | 96.0 ± 0.43 | 79.6 ± 0.86 | 66.3 ± 0.51 | 48.9 ± 1.93 | 96.6 ± 1.10 |
83.9 ± 0.84 b |
71.4 ± 0.24 # a, b |
53.5 ± 0.58 # a |
97.5 ± 0.36 |
86.0 ± 0.34 b |
75.0 ± 1.01 a, b, c |
56.7 ± 0.37 a, b, c |
98.8 ± 0.22 * |
86.8 ± 0.67 b |
74.8 ± 0.80 * a, b, c |
60.0 ± 1.41 * a, b, c |
| Percent Propofol Remaining in Remifentanil-Propofol Mixture (mean ± SEM; n = 3) | ||||||||||||||||||||
| W |
99.6 ± 0.21 c |
99.2 ± 0.21 d |
98.7 ± 0.20 b |
97.9 ± 0.21 c |
99.5 ± 0.16 c |
100.0 ± 0.21 d |
99.4 ± 0.10 ^ d |
98.3 ± 0.38 c |
100.6 ± 0.00 ^ |
99.7 ± 0.65 |
99.4 ± 0.32 d |
99.5 ± 0.17 ^ |
99.6 ± 0.19 c |
99.3 ± 0.40 |
99.0 ± 0.12 d |
97.8 ± 0.02 c |
100.1 ± 0.16 c |
98.0 ± 0.28 # |
96.9 ± 0.67 # |
97.9 ± 0.17 c |
| 0.9% | 100.8 ± 0.62 | 99.2 ± 0.58 | 98.6 ± 0.09 | 96.8 ± 0.97 | 98.0 ± 0.86 | 99.9 ± 0.53 | 98.0 ± 0.65 | 97.2 ± 0.59 | 98.6 ± 0.84 | 100.5 ± 1.80 | 100.5 ± 1.46 | 99.1 ± 1.58 | 100.1 ± 0.26 | 99.7 ± 0.15 | 98.3 ± 0.33 | 97.7 ± 0.06 | 99.6 ± 0.24 | 99.6 ± 0.11 | 99.3 ± 0.49 | 98.7 ± 0.49 |
| 20% | 99.8 ± 0.13 | 99.4 ± 0.62 | 98.6 ± 0.42 | 99.3 ± 0.49 | 99.0 ± 0.27 | 98.4 ± 0.74 | 97.7 ± 0.49 | 97.3 ± 0.79 | 99.5 ± 0.28 | 98.1 ± 0.89 | 97.9 ± 0.84 |
96.5 ± 0.64 a |
99.5 ± 0.24 | 99.4 ± 0.22 | 98.4 ± 0.35 |
97.2 ± 0.25 a |
99.2 ± 0.32 | 98.9 ± 0.31 | 98.5 ± 0.46 |
96.5 ± 0.86 a |
| pH of Solution (mean ± SEM; n = 6) | ||||||||||||||||||||
| W | 7.42 ± 0.12 | 7.41 ± 0.10 |
7.42 ± 0.12 ^ |
6.72 ± 0.40 |
7.19 ± 0.14 d |
7.18 ± 0.11 | 7.12 ± 0.13 | 6.66 ± 0.33 | 7.02 ± 0.16 |
6.98 ± 0.13 a |
6.95 ± 0.16 a |
6.55 ± 0.36 |
6.88 ± 0.20 a |
6.89 ± 0.18 a |
6.87 ± 0.18 a |
6.31 ± 0.43 |
6.59 ± 0.23 a |
6.67 ± 0.20 a |
6.67 ± 0.23 a |
6.20 ± 0.41 |
| 0.9% | 7.17 ± 0.04 | 7.17 ± 0.05 | 7.13 ± 0.09 | 6.63 ± 0.33 | 7.10 ± 0.08 | 7.05 ± 0.06 | 6.94 ± 0.06 | 6.64 ± 0.26 |
6.87 ± 0.08 a |
6.89 ± 0.07 a |
6.75 ± 0.06 a |
6.48 ± 0.28 |
6.68 ± 0.10 a, b |
6.74 ± 0.09 a, b |
6.66 ± 0.10 a, b |
6.12 ± 0.35 |
6.44 ± 0.16 a, b, c |
6.49 ± 0.14 a, b, c |
6.47 ± 0.15 a, b |
6.13 ± 0.33 |
| 20% |
7.01 ± 0.01 * |
7.00 ± 0.01 * |
6.94 ± 0.03 | 6.36 ± 0.31 |
6.79 ± 0.02 * a |
6.79 ± 0.02 * a |
6.69 ± 0.08 *, a |
5.95 ± 0.39 |
6.64 ± 0.02 * a, b |
6.66 ± 0.01 * a, b |
6.62 ± 0.03 a |
5.84 ± 0.38 |
6.51 ± 0.05 e |
6.53 ± 0.04 e |
6.48 ± 0.06 a |
5.72 ± 0.41 |
6.30 ± 0.06 a, b, c |
6.34 ± 0.06 a, b, c |
6.33 ± 0.08 a, b, c |
5.71 ± 0.36 |
W = water, 0.9% = 0.9% saline, 20% = 20% saline
*P < 0.05 vs. all other reconstitution solutions; #P < 0.05 vs. 0.9% saline solution; ^P < 0.05 vs. 20% saline solution
aP < 0.05 vs. 10 μg mL− 1; bP < 0.05 vs. 20 μg mL− 1; cP < 0.05 vs. 30 μg mL− 1; dP < 0.05 vs. 50 μg mL− 1; eP < 0.05 vs. all other concentrations