Fig. 3.

Noradrenaline induced inward current in pyramidal cells via α1 receptor. a Samples showing High dose (50 μM) but not low dose (10 μM) of NA produced inward currents. b Samples showing α1 receptors antagonist prazosin, but not α2 receptors antagonist yohimbine nor β1 receptors antagonist propranolol blocked the inward current induced by NA (50 μM). c Averaged results showing high dose but not low dose of NA induced inward current (10 μM NA: n = 13, 50 μM NA: n = 12, 100 μM NA: n = 12). The inward currents were blocked by α1 receptors antagonist, but not α2 receptors nor β receptors antagonist. High dose of NA (50 μM) produced inward current is blocked by Prazosin (10 μM NA: 0.34 ± 3.74 pA, n = 13; 50 μM NA: 23.73 ± 4.13 pA, n = 12; 100 μM NA: 15.69 pA ± 3.82 pA, n = 12; Prazosin:: − 5.94 ± 3.76 pA, n = 9; Yohimbine: 20.58 ± 4.59 pA, n = 8; Propranolol: 16.35 ± 4.79 pA, n = 8). *P < 0.05, 10 μM NA vs. 50 μM or 100 μM NA, Prazosin vs. Yohimbine or Propranolol. One-Way ANOVA