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. 2020 Nov 13;22:125. doi: 10.1186/s13058-020-01361-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ALK4^L75A-Fc reduces migration and proliferation in stressed breast cancer cells, Scale bar = 300m. a, b In vitro scratch wound filling by MDA-MB-231 cells treated with soluble ALK4^L75A-Fc protein under glucose restriction. Representative images from among 5 replicates per treatment are shown. c, d In vitro scratch wound filling of ALK4^L75A-Fc-expressing and mock, LVS14-transduced MDA-MB-231 cell cultures under glucose restriction. Representative images from among 5 replicates per treatment are shown. e ALK4^L75A-Fc inhibits MDA-MB-231 human breast cancer cells’ growth recovery from 2-DG treatment. Replicates = 3 *Student’s t test. f Maximum slope values from the graph in e. g Growth rate of MDA-MB-231 cells expressing shCRIPTO under 2-DG challenge and release, represented as maximum slope. All time-lapse studies were conducted with 3–5 replicates and were repeated 2–3 times