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. 2020 Aug 10;19(11):1826–1849. doi: 10.1074/mcp.RA120.002228

Fig. 3.

Fig. 3.

Characterization of protein networks for known ribosome interactors, SEC61β and RPN1. A, Comparison of protein abundance for the 353 identified putative interactors in SEC61β-BirA and empty vector control HEK293 cells. Purple dots represent enriched, high-confidence interactors. Gray dots represent identified proteins whose enrichments are below cutoff, and represent less likely bona fide interactors of SEC61β-BirA. B, Enriched Gene Ontology (GO) terms associated with high-confidence SEC61β-BirA interactors. Dark purple, purple, and light purple bars represent membrane-, endoplasmic reticulum (ER)-, and protein transport-related GO enriched terms, respectively. C, Protein-protein interactions (PPI) among high-confidence SEC61β-BirA interactors, based on STRING annotations. Pink and cyan edges indicate experimentally determined and curated interactions, respectively. D, Comparison of protein abundance for the identified 353 putative interactors in RPN1-BirA and empty vector control HEK293 cells. Green dots represent enriched, high-confidence proteins that interact with RPN1-BirA. Gray dots, as above, represent identified proteins that are less likely bona fide interactors of RPN1-BirA. E, PPI network among high-confidence RPN1-BirA interactors, based on STRING annotations. F, Functional comparison of all 13 high-confidence RPN1-BirA interactors, based on STRING annotations.