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. 2020 Oct 27;15(9):577–593. doi: 10.2217/fvl-2020-0188

Figure 3. . Differentially expressed long noncoding RNAs interact with SARS-CoV-2 protein interacting genes.

Figure 3. 

(A) M protein interactor AKAP8L interacts with downregulated KCNQ1OT1, GAS6-AS1, SNHG8, AC048341.2 and upregulated AL109615.3. (B) Among N protein interactors, UPF1 and MOV10 proteins interacts directly with multiple DE lncRNAs, and each other. Both also interact with ADAR protein. (C) MEG3 can stimulate expression of GDF15, an interactor of viral protein orf8. (D) Nsp8 interactors EXOSC5 and LARP7 proteins interact with downregulated KCNQ1OT1 and SNHG8; HECTD1 mRNA interacts with KCNQ1OT1. Nsp12 interactor LARP4B protein interacts with downregulated UGDH-AS1 and SNHG8, and also with LARP7. (E) Nsp13 interactors MIPOL1 and PRKAR2A interact with downregulated KCNQ1OT1; PRKAR2A also interacts with UGDH-AS1 interactor EDN1. Color codes, node and edge notations are similar as Figure 2.

DE: Differentially expressed; lncRNAs: Long noncoding RNAs.