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Keap-Nrf2-ARE pathway. A proposed mechanism for the antioxidant property of OPP. ⊕: activate or stimulate; RNS: reactive nitrogen species; ROS: reactive oxygen species; Nrf2: nuclear factor erythroid 2-related factor 2; KEAP1: Kelch-like ECH-associated protein 1; sMaf: small Maf proteins; ARE: antioxidant response element.
