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. 2020 Nov 6;21(21):8320. doi: 10.3390/ijms21218320

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation of chromatin structure by hypoxia on a global and locus-specific level. Independent of the HIF transcriptional pathway, hypoxia globally inhibits the activity of many 2-OG dependent dioxygenases that control histone and DNA modifications. The HIF transcription factor complex, activated by hypoxia, also works to control histone and DNA modifications on a global level by transcriptional induction of these same readers and writers. To cause locus-specific effects, HIF recruits these enzymes to chromatin and activates the RNApol2 complex.