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. 2020 Nov 5;21(21):8313. doi: 10.3390/ijms21218313

Figure 7.

Figure 7

JMJD2B stimulated LXRα-activated transcriptional activity of LXRE-containing luciferase reporters. (A) HepG2 cells were transfected with Luc-reporters including 3xLXRE-Luc, SREBF1-Luc and FAS-Luc, and JMJD2B expression vector (pCMV-JMJD2B), then incubated with T0901317 for 24 h. Luciferase activities were determined using a kit. Data are presented as the mean ± SD from three independent experiments. * p < 0.05 vs. only T0901317 treatment. (B) HepG2 cells were transfected with Luc-reporters, JMJD2B expression vector (pCMV-JMJD2B), and LXRα expression vector (pCMV-LXRα). Luciferase activities were determined using a kit. ** p < 0.01 vs. only pCMV-LXRα.