Table 1.

Nrf2-associated, upregulated genes upon long-term exposure to PM_2.5.

Gene Symbol	Encoded Protein	p-Value	log2FC	FC
AKR1C1 ‡	aldo-keto reductase family 1 member C1	0.0043	1.53	2.89
AKR1C2 ‡	aldo-keto reductase family 1 member C2	0.0038	1.66	3.16
AKR1C3 ‡	aldo-keto reductase family 1 member C3	0.0066	1.25	2.38
CYP1A1 §	cytochrome P450, family 1, subfamily A, polypeptide 1	0.0011	2.54	5.82
EGR1 †	early growth response 1	0.0080	1.01	2.02
EREG ‡	Epiregulin	0.0008	2.73	6.65
FAM83B ‡	family with sequence similarity 83, member B	0.0058	1.26	2.40
GCLC §	glutamate-cysteine ligase, catalytic subunit	0.0197	0.80	1.74
GOS2 ‡	switch protein 2	0.0017	1.25	2.37
GREM1 ‡	gremlin 1, DNA family BMP antagonist	0.0017	2.85	7.20
HMOX1 †,‡	heme oxygenase (decycling) 1	0.0035	1.23	2.34
IL1A ‡	interleukin 1, alpha	0.0014	2.32	5.00
ITGA2 ‡	integrin, alpha 2	0.0011	1.54	2.90
NQO1 §	NAD(P)H dehydrogenase, quinone 1	0.0482	0.71	1.64
S100A9 ‡	S100 calcium binding protein A9	0.0052	2.05	4.15
SLC7A11 †	solute carrier family 7 (anionic amino acid transporter light chain, xc-system), member 11; xCT	0.0072	1.69	3.24
SPOCK1 ‡	sparc/osteonectin	0.0080	1.04	2.05
STEAP1 ‡	six transmembrane epithelial antigen of the prostate1	0.0059	1.34	2.53
STC2 ‡	stanniocalcin 2	0.0090	0.79	1.73
TPBG ‡	trophoblast glycoprotein	0.0038	0.93	1.91
TGFA †,‡	transforming growth factor, alpha	0.0038	2.04	4.10

^† functional enrichment by WikiPathway analysis; ^‡ according to enriched transcription factor binding sites; ^§ other Nrf2 associated upregulated genes, relevant for antioxidant or xenobiotic responses.