Table 2.
Patient baseline characteristics with regard to the TIM-3 rs10515746 genotypes.
| Characteristics | All (n = 712) |
AA + AC (n = 247) |
CC (n = 465) |
p-Value |
|---|---|---|---|---|
| Basic Conditions | ||||
| Age [years] | 63 ± 15 | 63 ± 15 | 63 ± 15 | 0.9536 |
| Male sex [%] | 65 | 68 | 64 | 0.2451 |
| Body mass index (BMI) [kg/m2] | 28 ± 7 | 28 ± 8 | 28 ± 6 | 0.7976 |
| Severity on Sepsis Onset (Day 1) | ||||
| Sequential Organ Failure Assessment (SOFA) |
10 ± 4 | 10 ± 4 | 10 ± 4 | 0.9343 |
| Acute Physiology And Chronic Health Evaluation (APACHE II) |
22 ± 7 | 21 ± 7 | 22 ± 7 | 0.1738 |
| Procalcitonin [ng/dl] | 10 ± 29 | 12 ± 34 | 9 ± 25 | 0.7732 |
| Use of vasopressor [%] | 70 | 70 | 69 | 0.7857 |
| Mechanical ventilation [%] | 86 | 85 | 87 | 0.3181 |
| Renal replacement therapy [%] | 10 | 12 | 9 | 0.2123 |
| Comorbidities [%] | ||||
| Arterial hypertension [%] | 54 | 53 | 54 | 0.6908 |
| Chronic obstructive pulmonary disease (COPD) [%] |
15 | 13 | 16 | 0.3269 |
| Bronchial asthma [%] | 3 | 2 | 3 | 0.5325 |
| Renal dysfunction [%] | 10 | 12 | 9 | 0.3401 |
| Non-insulin-dependent diabetes mellitus (NIDDM) [%] |
9 | 8 | 9 | 0.6736 |
| Insulin-dependent diabetes mellitus (IDDM) [%] | 10 | 10 | 10 | 0.9953 |
| Chronic liver disease [%] | 6 | 6 | 6 | 0.7929 |
| History of myocardial infarction [%] | 5 | 5 | 6 | 0.8546 |
| History of stroke [%] | 6 | 5 | 6 | 0.5211 |
| History of cancer [%] | 14 | 17 | 12 | 0.1095 |
| Medication on Sepsis Onset [%] | ||||
| Statins [%] | 23 | 24 | 23 | 0.6532 |
| Beta-blocker [%] | 37 | 38 | 36 | 0.7305 |
| ACE inhibitor [%] | 29 | 32 | 28 | 0.2832 |
| Bronchodilator [%] | 10 | 6 | 12 | 0.0155 |
| Diuretics [%] | 33 | 34 | 33 | 0.8960 |
| Anticoagulation during the last 6 months [%] | 25 | 28 | 24 | 0.3142 |
| Recent Surgical History [%] | ||||
| Elective surgery [%] | 27 | 25 | 29 | |
| Emergency surgery [%] | 52 | 54 | 51 | 0.5589 |
| No surgery [%] | 21 | 21 | 21 | |
| Site of Infection [%] | ||||
| Lung [%] | 63 | 62 | 64 | |
| Abdomen [%] | 19 | 22 | 17 | |
| Bone or soft tissue [%] | 3 | 2 | 4 | |
| Surgical wound [%] | 2 | 2 | 2 | 0.2890 |
| Urogenital [%] | 2 | 2 | 3 | |
| Primary bacteremia [%] | 6 | 6 | 6 | |
| Other [%] | 5 | 5 | 5 |
p-values calculated using Mann–Whitney U test, Pearson’s chi-square test, or two-sided Fisher’s exact test.