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. 2020 Sep 26;7(11):2137–2149. doi: 10.1002/acn3.51205

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Scn1b deletion impairs inhibitory neurotransmission. (A) Representative sIPSC traces from whole‐cell recordings from layer 6 pyramidal neurons of Scn1b ^+/+ (black) and Scn1b ^‐/‐ (red) mice. (B) Cumulative probability plots of sIPSC amplitude (n/N = 12/4 Scn1b ^+/+, 12/4 Scn1b ^‐/‐) as in A. Inset bar graphs show mean sIPSC amplitude. (C) Cumulative probability plot of interevent intervals as in A. Top asterisks indicate P‐value for comparing cumulative probabilities (****P < 0.0001, Kolmogorov–Smirnov test). Inset bar graphs shown mean sIPSC frequency (1/IEI). Asterisk indicates P‐value (***P < 0.005, Welch’s t‐test).