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Expression of Mismatch Repair (MMR) Proteins by Immunohistochemistry in 82 MMR-Deficient Colorectal Cancers without MLH1 Methylation.
| Cases (n) | MLH1 | PMS2 | MSH2 | MSH6 | |
|---|---|---|---|---|---|
| Lynch syndrome, Missense Mutations (9) | Unexpected Staining (4) | 0 | 2 | 0 | 2 |
| Expected Staining (5) | 0 | 0 | 4 | 1 | |
| Lynch syndrome, Truncating Mutations (47) | Unexpected Staining (5) | 1 | 1 | 0 | 3 |
| Expected Staining(42) | 6 | 8 | 21 | 7 | |
| Double Somatic MMR Mutations (26) | Unexpected Staining (7) | 6 | 0 | 1 | 0 |
| Expected Staining(19) | 14 | 0 | 3 | 2 | |
