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. Author manuscript; available in PMC: 2020 Nov 13.
Published in final edited form as: Vasc Med. 2019 Aug 26;24(5):395–404. doi: 10.1177/1358863X19866254

Figure 2.

Figure 2.

Knockdown of DUSP5 in C57BL/6 mice is associated with impaired perfusion recovery and limb necrosis following HLI. (a) Gene expression of DUSP5 in control shRNA versus DUSP5 shRNA-treated day 3 post-ischemic mouse GA muscle tissue lysates. (b) Mice treated with DUSP5 shRNA showed impaired perfusion recovery compared with mice treated with control shRNA. Bars represent mean ± SEM (n = 13–14, **p < 0.01). (c) Representative perfusion images of control versus DUSP5 shRNA-treated mice post-HLI. (d) Representative images of necrosis in the control versus DUSP5 shRNA-treated mice. (e) Necrosis score in control shRNA versus DUSP5 shRNA-treated mice.

D, day; DUSP5, dual specificity phosphatase 5; GA, gastrocnemius; HLI, hind limb ischemia; KD, knockdown; shRNA, small hairpin RNA; W, week.